Andes virus envelope glycoprotein Gn (Gn)

Andes virus envelope glycoprotein Gn is a structural glycoprotein present on the surface of Andes virus, a highly pathogenic member of the Hantavirus genus (family Hantaviridae). Gn, together with the Gc glycoprotein, forms heterodimeric and tetrameric spike complexes that constitute the virus's outer envelope lattice. The Gn glycoprotein is essential for viral assembly, cell entry (including receptor binding and trafficking), and budding. Its cytoplasmic tail mediates critical interactions with ribonucleoprotein particles necessary for viral replication and assembly[1][2][4][7][8]. Structurally, Gn is a type I transmembrane protein with a large ectodomain and a cytoplasmic tail that includes a zinc finger domain implicated in protein–protein binding[1][2]. Gn is immunogenic, representing a principal target for virus-neutralizing antibodies and a candidate for vaccine development[4][5][7]. Andes virus and its glycoproteins are the central agents in hantavirus cardiopulmonary syndrome (HCPS) in South America, for which there are no approved therapeutics; current medical research aims to exploit Gn as a therapeutic and diagnostic target[4][7][8].

Other names

GnHantavirus envelope glycoprotein GnEnvelope protein N (Gn)

Inhibiting virus–cell entry (by blocking Gn/host receptor or interfering with spike function; mainly theoretical or vaccine/antibody-based) Inhibiting glycoprotein-mediated fusion