Androgen-dependent TFPI-regulating protein (ADTRP)

Androgen-dependent TFPI-regulating protein (ADTRP) is a membrane-associated enzyme encoded by the ADTRP gene (previously C6orf105) and is primarily expressed in endothelial cells. It is inducible by androgens and plays a critical role in regulating the expression and activity of tissue factor pathway inhibitor (TFPI), the major inhibitor of the tissue factor-dependent coagulation pathway. ADTRP also demonstrates hydrolase activity specific for fatty acid esters of hydroxy fatty acids (FAHFAs), contributing to anti-diabetic and anti-inflammatory lipid metabolism. Functionally, ADTRP supports vascular development and barrier integrity, in part by modulating Wnt signaling and matrix metalloproteinase-9 (MMP-9) expression. Genetic variants of ADTRP are associated with several vascular diseases, including coronary artery disease and thrombosis, and its deficiency can cause abnormal angiogenesis, vascular leakage, and increased inflammation.

Other names

AIG1LC6orf105dJ413H6.1FAHFA hydrolase ADTRPAndrogen-induced 1-likeFatty acid esters of hydroxy fatty acids hydrolase ADTRPandrogen-dependent TPF1-regulating protein