Androgen-induced gene 1 protein (AIG1)

Androgen-induced gene 1 protein (AIG1) is a human protein encoded by the AIG1 gene, located on chromosome 6. It is a membrane-associated enzyme that hydrolyzes bioactive fatty acid esters of hydroxy fatty acids (FAHFAs), but does not act on other major lipid classes[2][3][4][5]. AIG1 is implicated in the regulation of long-chain fatty acid catabolism and has been shown to play a role in cellular signal transduction, specifically by modulating the NFAT signaling pathway[6]. Disease associations include amebiasis and myxosarcoma, and as an enzyme with unique lipid substrate specificity, it is a candidate for further study as a potential therapeutic target[2][6]. No known direct drug modulators or established clinical biomarkers are currently reported for AIG1.

Other names

Androgen induced 1AIG-1dJ95L4.1CGI-103FLJ10485Fatty acid esters of hydroxy fatty acids hydrolase AIG1FAHFA hydrolase AIG1androgen-induced gene 1 protein

Hydrolyzes (breaks down) fatty acid esters of hydroxy fatty acids (FAHFAs), modulates NFAT signaling