Angiogenesis in adipose tissue

Angiogenesis in adipose tissue refers to the process by which new blood vessels form within fat depots. This process is critical for healthy adipose tissue expansion, function, and remodeling, as capillary networks deliver oxygen, nutrients, and signaling molecules required for adipocyte survival and function. In health, angiogenesis enables adipose tissue to expand and remodel in response to metabolic needs. In obesity, angiogenic processes become dysregulated, leading to hypoxia, inflammation, and metabolic dysfunction. The process is controlled by a complex interplay of cellular interactions (mainly between endothelial cells and adipocytes), secreted factors such as VEGF, FGF2, and adipokines, and by the tissue microenvironment[1][2][3][4]. Therapeutically targeting angiogenesis in adipose tissue has been proposed for obesity and metabolic disease treatments, but does not correspond to a specific single molecule or receptor[7]. Note: If you are seeking structured information on specific molecular targets (such as VEGFR2, PDGFR, FGF receptors, or PPARγ) involved in adipose tissue angiogenesis, it would be recommended to specify one of these molecules by name.

Other names

Adipose tissue angiogenesisangiogenic process in fatneovascularization in adipose tissue

Promotion or inhibition of new capillary formation in adipose tissue via modulation of endothelial cell behavior Modulation of pro-angiogenic factors (VEGF, FGF2, angiopoietins, etc.) or inhibitors Influence on adipocyte differentiation and metabolic activity through vascular remodeling