Angiogenesis promotion via paracrine signaling factors

The phrase "angiogenesis promotion via paracrine signaling factors" encompasses the complex, localized secretion of growth factors, cytokines, and chemokines by cells to stimulate the formation of new blood vessels in neighboring tissues. Paracrine signaling is a key mechanism by which endothelial and stromal cells coordinate angiogenesis during normal development, tissue repair after injury, and pathological states such as tumor growth. The most prominent growth factors mediating this effect are vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), platelet-derived growth factor (PDGF), and others, which bind their respective transmembrane receptors on endothelial cells to activate signal transduction cascades that promote cell proliferation, migration, survival, and differentiation[1][7][8]. Inhibiting these pathways forms the basis for many anti-angiogenesis drugs used clinically, especially in cancer therapy, but can lead to significant safety concerns due to VEGF’s role in maintaining normal vasculature[4][7].

Other names

Angiogenesis via paracrine factorsParacrine angiogenic factors signalingParacrine-mediated angiogenesis

Inhibition of growth factor binding to receptor (e.g., anti-VEGF antibody); Blockade of receptor tyrosine kinase activation (small-molecule kinase inhibitors); Disruption of ligand-induced signal transduction for angiogenesis