Angiogenesis regulation via exerkines

"Angiogenesis regulation via exerkines" does not refer to a single molecule or receptor but rather describes the process by which **exerkines**—a diverse group of humoral factors released in response to acute or chronic exercise—modulate the formation of new blood vessels. Exerkines include cytokines, peptides, and metabolites secreted from skeletal muscle and other organs during physical activity. Notable examples are interleukin‑6 (IL‑6) and fibroblast growth factor 21 (FGF21), both shown to influence metabolic adaptation, tissue regeneration, and vascular remodeling. For instance, FGF21 sensitivity in cardiac tissue is increased by endurance exercise, promoting myocardial angiogenesis and protecting against ischemic injury. The term itself is not a canonical target but an umbrella for multiple molecular mediators involved in exercise-induced physiological responses related to vascular health[1][2][3].

Other names

Exerkine-mediated angiogenesis regulationAngiogenesis via exerkinesExercise-induced angiogenic signaling

Exerkines act as messengers released during exercise that can promote or regulate the formation of new blood vessels (angiogenesis) in various tissues by modulating signaling pathways such as FGF21/FGF receptor/KLB axis and IL‑6/GLP‑1 axis[1].