Angiogenesis via Paracrine Signaling

Angiogenesis via paracrine signaling is the process of new blood vessel formation stimulated by factors secreted from nearby cells. Key paracrine factors include VEGF, HGF, IGF-1, IL-8, IL-6, PDGF, and TGF-β1, which promote endothelial cell proliferation, migration, and vessel stabilization. Dysregulation of this process contributes to diseases like cancer and ischemic disease, making it a therapeutic target for both inhibiting excessive angiogenesis and promoting it for tissue repair.

Other names

Paracrine-mediated AngiogenesisNeovascularization via Paracrine Factors

Paracrine signaling involves the secretion of soluble proteins or vesicles by source cells, diffusion through the local microenvironment, binding to specific receptors on target/endothelial cells, and activation of intracellular pathways leading to endothelial cell proliferation, migration, tube formation/capillary network assembly, and vessel maturation/stabilization.