Angiogenic growth factor secretion

Angiogenic growth factor secretion" refers to the process by which various cell types—including endothelial cells, fibroblasts, and tumor cells—release signaling proteins known as angiogenic growth factors into their environment. These secreted factors, such as vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), and platelet-derived growth factor (PDGF), act in paracrine and autocrine fashions to stimulate the sprouting, proliferation, and migration of endothelial cells, ultimately forming new blood vessels. This process is tightly regulated and is critical for physiological events such as embryonic development, tissue repair, and regeneration, but also plays a key role in pathological states like cancer, where aberrant or excessive secretion of angiogenic growth factors drives tumor vascularization and progression[1][3][4][5][6][7][12].

Other names

Angiogenic factor secretion