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Target intelligence / Profile preview
Angiopoietin-like 3 (ANGPTL3)
- Target
- ANGPTL3
- Molecular classification
- Secreted protein, Enzyme inhibitor
01
Overview
ANGPTL3 is a secreted protein primarily expressed in the liver that plays a critical role in lipid metabolism and angiogenesis. It functions as a dual inhibitor of lipoprotein lipase (LPL) and endothelial lipase (EL), leading to increased levels of triglycerides, LDL-C, and HDL-C in plasma. ANGPTL3 also promotes endothelial cell adhesion and migration. Loss-of-function mutations in ANGPTL3 are associated with hypolipidemia, making it a therapeutic target for lowering LDL-C.
- Other names
- angiopoietin-like protein 3
02
Mechanism of action
Inhibition of lipoprotein lipase (LPL) and endothelial lipase (EL)
03
Biological functions
Lipid metabolismAngiogenesisInhibition of lipoprotein lipase (LPL)Inhibition of endothelial lipase (EL)Regulation of triglyceride levelsRegulation of LDL-C levelsRegulation of HDL-C levelsEndothelial cell adhesionEndothelial cell migration
04
Disease associations
Familial combined hypolipidemiaFamilial hypobetalipoproteinemia type 2Developmental and epileptic encephalopathy 23Cardiovascular diseaseLipid disorders
05
Safety considerations
Potential impact on fatty acid metabolismPossible effects on angiogenesis
06
Biomarkers
ANGPTL3 serum levels (for patient selection/efficacy monitoring in ANGPTL3-targeted therapies)
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