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Angiopoietin-like 3 protein (ANGPTL3)
- Target
- ANGPTL3
- Molecular classification
- Angiopoietin-like proteins (ANGPTLs), Secreted glycoprotein
01
Overview
Angiopoietin-like 3 protein (ANGPTL3) is a secreted glycoprotein primarily expressed in the liver. It plays a central role in lipid metabolism by inhibiting lipoprotein lipase (LPL) and endothelial lipase (EL), thereby modulating triglyceride, LDL-C, and HDL-C levels. It is also involved in angiogenesis through interactions with integrins on endothelial cells. ANGPTL3 is a promising molecular target for reducing CHD risk.
- Other names
- ANGPTL3
02
Mechanism of action
Inhibition of LPL and EL, leading to increased plasma triglyceride, LDL-C, and HDL-C levels. Also interacts with integrins to promote cell adhesion and migration.
03
Biological functions
Regulation of lipid metabolismInhibition of lipoprotein lipase (LPL)Inhibition of endothelial lipase (EL)Regulation of angiogenesisCell adhesionCell migration
04
Disease associations
Cardiovascular diseaseCoronary artery diseaseFamilial combined hypolipidemiaColorectal cancerLiver metastasis
05
Biomarkers
Plasma ANGPTL3 levels
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