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Target intelligence / Profile preview
Angiopoietin-like 4 (ANGPTL4)
- Target
- ANGPTL4
- Molecular classification
- Secreted glycoprotein, Angiopoietin-like protein
01
Overview
Angiopoietin-like 4 (ANGPTL4) is a secreted glycoprotein that plays a central role in regulating lipid metabolism by inhibiting lipoprotein lipase (LPL). It is also involved in glucose homeostasis, vascular biology, and inflammation. ANGPTL4's effects are context-dependent, and its role in diseases like cancer and nephrotic syndrome is complex and influenced by factors like its sialylation state.
- Other names
- Fasting-Induced Adipose Factor (FIAF)Hepatic fibrinogen/angiopoietin-related proteinAngiopoietin-related protein 4
02
Mechanism of action
Inhibition of LPL activity, activation of intracellular lipolysis, modulation of endothelial cell function.
03
Biological functions
Lipid metabolism regulationGlucose homeostasisVascular biologyEndothelial function modulationInflammation regulationOxidative stress response
04
Disease associations
HypertriglyceridemiaAtherosclerosisCancerNephrotic SyndromeCardiovascular disease
05
Safety considerations
Potential for context-dependent effects in cancer (tumor promotion or suppression)Modulation of inflammatory pathways with potential for unintended consequencesEffects on endothelial dysfunction and atherosclerosis
06
Biomarkers
Plasma ANGPTL4 levels (for cardiovascular mortality risk)Sialylation state of ANGPTL4 (for nephrotic syndrome)
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