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Target intelligence / Profile preview
Angiopoietin-like protein 3 (ANGPTL3)
- Target
- ANGPTL3
- Molecular classification
- Angiopoietin-like proteins
01
Overview
Angiopoietin-like protein 3 (ANGPTL3) is a secreted glycoprotein primarily expressed in the liver and plays a central role in lipid metabolism, angiogenesis, and disease states related to lipid disorders. It inhibits lipoprotein lipase (LPL) and endothelial lipase (EL), leading to increased plasma levels of triglycerides and affecting HDL metabolism. Inhibition of ANGPTL3 is a therapeutic target for dyslipidemias.
- Other names
- ANGPTL3
02
Mechanism of action
Inhibition of ANGPTL3 reduces plasma LDL cholesterol and triglycerides.
03
Biological functions
Regulation of lipid metabolismInhibition of lipoprotein lipase (LPL)Inhibition of endothelial lipase (EL)Promotion of angiogenesisStem cell expansionInflammation modulationTissue remodeling
04
Disease associations
Familial combined hypolipidemiaDyslipidemiaCardiovascular diseaseCancer
05
Safety considerations
Potential impact on angiogenesisLong-term effects of ANGPTL3 inhibition are still being studied
06
Interacting drugs
Monoclonal antibodies targeting ANGPTL3
1 more in the full profile.
07
Biomarkers
Plasma levels of ANGPTL3LDL-C levelsHDL-C levelsTriglyceride levels
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