Drug pipeline
Explore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Angiopoietin-like protein 3 (ANGPTL3)
- Target
- ANGPTL3
- Molecular classification
- Angiopoietin-like proteins
01
Overview
Angiopoietin-like protein 3 (ANGPTL3) is a secreted glycoprotein primarily expressed in the liver and plays a central role in lipid metabolism, angiogenesis, and disease states related to lipid disorders. It inhibits lipoprotein lipase (LPL) and endothelial lipase (EL), leading to increased plasma levels of triglycerides and affecting HDL metabolism. Inhibition of ANGPTL3 is a therapeutic target for dyslipidemias.
- Other names
- ANGPTL3
02
Mechanism of action
Inhibition of ANGPTL3 reduces plasma LDL cholesterol and triglycerides.
03
Biological functions
Regulation of lipid metabolismInhibition of lipoprotein lipase (LPL)Inhibition of endothelial lipase (EL)Promotion of angiogenesisStem cell expansionInflammation modulationTissue remodeling
04
Disease associations
Familial combined hypolipidemiaDyslipidemiaCardiovascular diseaseCancer
05
Safety considerations
Potential impact on angiogenesisLong-term effects of ANGPTL3 inhibition are still being studied
06
Interacting drugs
Monoclonal antibodies targeting ANGPTL3
1 more in the full profile.
07
Biomarkers
Plasma levels of ANGPTL3LDL-C levelsHDL-C levelsTriglyceride levels
Beyond the preview
Go deeper on Angiopoietin-like protein 3 (ANGPTL3).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Follow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Compare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Investigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Explore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Connect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Angiopoietin-like protein 3 (ANGPTL3).