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Angiopoietin-like Protein 3 Messenger RNA (ANGPTL3 mRNA)
- Target
- ANGPTL3 mRNA
- Molecular classification
- RNA, mRNA
01
Overview
Angiopoietin-like protein 3 (ANGPTL3) is a secreted protein primarily produced in the liver. The messenger RNA (mRNA) for ANGPTL3 serves as the template for synthesis of the ANGPTL3 protein, a key regulator of lipid metabolism. ANGPTL3 inhibits lipoprotein lipase (LPL) and endothelial lipase (EL), influencing plasma triglyceride and cholesterol levels. Genetic or pharmacological inhibition of ANGPTL3 mRNA, and subsequent protein production, leads to reduced blood lipids and potential cardiovascular benefits. Therapies targeting ANGPTL3 mRNA are being developed for the treatment of dyslipidemia.
- Other names
- ANGPTL3 mRNAAngiopoietin-like 3 mRNA
02
Mechanism of action
siRNA/antisense oligonucleotide-mediated degradation of ANGPTL3 mRNA, leading to reduced ANGPTL3 protein production.
03
Biological functions
Template for protein synthesisRegulation of lipid metabolismAngiogenesis
04
Disease associations
DyslipidemiaCardiovascular disease
05
Interacting drugs
ARO-ANG3
06
Biomarkers
ANGPTL3 mRNA levelsTriglyceridesLDL-CHDL-C
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