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Target intelligence / Profile preview
Angiopoietin Receptor TIE2 (TIE2)
- Target
- TIE2
- Molecular classification
- Receptor, Receptor Tyrosine Kinase
01
Overview
TIE2/TEK is a critical endothelial-specific receptor tyrosine kinase mediating responses to angiopoietins. It orchestrates blood vessel stabilization during development but also plays key roles in disease-related neovascularization. Its unique structure enables specific ligand interactions that regulate downstream signaling essential for vascular health—and makes it an attractive target for therapies aimed at controlling abnormal blood vessel growth in cancer and other pathologies.
- Other names
- TEKAngiopoietin-1 receptorCD202B
02
Mechanism of action
Inhibition of Angiopoietin-TIE2 interaction to prevent pathological angiogenesis.
03
Biological functions
Vascular developmentVessel maturationEndothelial cell survivalAngiogenesis regulation
04
Disease associations
Venous malformationsCancerInflammatory diseasesPathological neovascularization
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