Molecular Classification
Receptor, Receptor Tyrosine Kinase
Other Names
TEK, Angiopoietin-1 receptor, CD202B
Disease Roles
Venous malformationsCancerInflammatory diseases

Angiopoietin Receptor TIE2 Overview

TIE2/TEK is a critical endothelial-specific receptor tyrosine kinase mediating responses to angiopoietins. It orchestrates blood vessel stabilization during development but also plays key roles in disease-related neovascularization. Its unique structure enables specific ligand interactions that regulate downstream signaling essential for vascular health—and makes it an attractive target for therapies aimed at controlling abnormal blood vessel growth in cancer and other pathologies.

Mechanism of Action

Inhibition of Angiopoietin-TIE2 interaction to prevent pathological angiogenesis.

Biological Functions

Vascular development
Vessel maturation
Endothelial cell survival
Angiogenesis regulation

Disease Associations

Venous malformations
Cancer
Inflammatory diseases
Pathological neovascularization

Safety Considerations

No safety concerns listed