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Target intelligence / Profile preview
Angiopoietin-Related Protein Tyrosine Kinase 2 (TIE2)
- Target
- TIE2
- Molecular classification
- Receptor Tyrosine Kinase
01
Overview
TIE2, also known as TEK or CD202B, is a receptor tyrosine kinase primarily expressed on endothelial cells. It serves as a key regulator of angiogenesis, vascular maturation, and endothelial cell survival. It is activated by Angiopoietin-1 (ANGPT1) and modulated by Angiopoietin-2 (ANGPT2). Its dysregulation is implicated in various diseases involving abnormal vessel growth/leakage, including cancer and retinal diseases. Therapeutic strategies are being explored to modulate the Tie2 pathway for treating these disorders.
- Other names
- TEKAngiopoietin-1 receptorCD202B
02
Mechanism of action
Modulation of Tie2 pathway to inhibit abnormal vessel growth/leakage.
03
Biological functions
AngiogenesisVascular developmentVessel maturationEndothelial cell survivalRegulation of vascular permeability
04
Disease associations
Venous malformationsTumor angiogenesisDiabetic retinopathyAge-related macular degenerationSepsis-induced vascular leakage
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