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Angiostatin
- Molecular classification
- Proteolytic fragment, Kringle domain protein
01
Overview
Angiostatin is a naturally occurring protein fragment derived from plasminogen that acts as an endogenous inhibitor of angiogenesis. It consists of multiple kringle domains and exerts its anti-angiogenic effects by binding to various proteins on endothelial cell surfaces, disrupting signaling pathways related to VEGF and nitric oxide, and modulating mitochondrial function. Its ability to inhibit tumor-induced neovascularization has led to clinical trials exploring its use in cancer therapy.
02
Mechanism of action
Inhibition of angiogenesis by blocking endothelial cell migration and proliferation, and by inducing apoptosis in endothelial cells; modulation of mitochondrial function
03
Biological functions
Angiogenesis inhibitionEndothelial cell migration inhibitionEndothelial cell proliferation inhibitionApoptosis inductionVEGF signaling modulationNitric oxide production modulation
04
Disease associations
Cancer
05
Safety considerations
Potential impairment of physiological vascular responses
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