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Target intelligence / Profile preview
Angiotensin-Converting Enzyme (ACE)
- Target
- ACE
- Molecular classification
- Enzyme, Zinc metalloprotease
01
Overview
Angiotensin-converting enzyme (ACE) is a zinc-dependent metalloproteinase that plays a central role in the renin–angiotensin system (RAS), which regulates blood pressure and fluid balance in the body. ACE converts angiotensin I to angiotensin II, a potent vasoconstrictor, and degrades bradykinin, a vasodilator. ACE is targeted pharmacologically by ACE inhibitors, which are widely used antihypertensive drugs.
- Other names
- Kininase II
02
Mechanism of action
ACE inhibitors block the conversion of angiotensin I to angiotensin II and prevent the degradation of bradykinin, leading to vasodilation and decreased blood pressure.
03
Biological functions
Regulation of blood pressureRegulation of fluid balanceConversion of Angiotensin I to Angiotensin IIDegradation of bradykininRegulation of vascular toneModulation of inflammationModulation of vascular permeability
04
Disease associations
Cardiovascular diseaseKidney diseaseHypertensionHeart failure
05
Interacting drugs
Captopril
2 more in the full profile.
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