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Target intelligence / Profile preview
Angiotensin-converting enzyme 2 (ACE2) Receptor Binding Domain of SARS-CoV-2 Spike Protein (SARS-CoV-2 Spike RBD - ACE2)
- Target
- SARS-CoV-2 Spike RBD - ACE2
- Molecular classification
- Protein-protein interaction, Receptor-ligand interaction
01
Overview
The interaction between the angiotensin-converting enzyme 2 (ACE2) receptor and the receptor binding domain (RBD) of the SARS-CoV-2 spike protein is crucial for viral entry into host cells. ACE2, a membrane-bound carboxypeptidase involved in blood pressure regulation, is exploited by the virus for attachment and subsequent cell entry. This interaction is a primary target for therapeutic intervention, including neutralizing antibodies, small molecule inhibitors, and vaccine design, aimed at disrupting virus-cell fusion and preventing infection.
- Other names
- SARS-CoV-2 Spike RBDACE2 Receptor Binding DomainSpike RBD - ACE2 complexRBD-ACE2 interaction
02
Mechanism of action
Inhibition of viral entry by blocking the interaction between the SARS-CoV-2 spike RBD and the ACE2 receptor.
03
Biological functions
Viral entryReceptor bindingAngiotensin II conversionAngiotensin-(1-7) production
04
Disease associations
COVID-19SARSCardiovascular diseaseInflammation
05
Safety considerations
Potential for off-target effects of ACE inhibitorsDevelopment of resistance to neutralizing antibodiesPossible immune-related adverse events
06
Interacting drugs
Neutralizing antibodies
3 more in the full profile.
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