Target intelligence / Profile preview

Angiotensin I (Ang I)

Target: Ang I
Molecular classification: Peptide hormone precursor, Precursor protein

Overview

Angiotensin I is a decapeptide that serves as an important precursor in the renin–angiotensin system, which regulates blood pressure and fluid balance. It is produced by the enzymatic action of renin on angiotensinogen. Angiotensin I itself has little to no direct biological activity but is crucial as it is converted into angiotensin II, a potent vasoconstrictor.

Other names: ProangiotensinPepsitansin

Mechanism of action

N/A (Angiotensin I is a substrate, not a target)

Biological functions

Precursor processingRegulation of blood pressure (indirect)Substrate for Angiotensin-Converting Enzyme (ACE)

Disease associations

Hypertension (indirectly)Cardiovascular disease (indirectly)

Interacting drugs

ACE inhibitors

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