Angiotensin II Type 1 Receptor β-Arrestin Pathway (AT1R β-arrestin pathway)

The Angiotensin II type 1 receptor (AT1R) β-arrestin pathway is a signaling cascade initiated by angiotensin II binding to the AT1R, a G protein-coupled receptor. This pathway involves the recruitment of β-arrestins, which desensitize G protein signaling and initiate distinct intracellular signaling cascades, including MAPK activation. This pathway plays a critical role in cardiovascular regulation and is implicated in various cardiovascular diseases. Selective modulation of this pathway is being explored for therapeutic potential.

Other names

AT1R beta-arrestin signalingAngiotensin Receptor Type 1 Beta-arrestin pathwayAGTR1 beta-arrestin pathway

Activation of β-arrestin signaling upon AT1R stimulation, leading to receptor internalization, desensitization of G protein signaling, and activation of alternative downstream signaling cascades (e.g., MAPK pathways).