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Target intelligence / Profile preview
Angiotensin Type 1 Receptor (AT1)
- Target
- AT1
- Molecular classification
- G protein-coupled receptor, GPCR, Receptor
01
Overview
The angiotensin II type 1 receptor (AT1, also known as AGTR1) is a G protein-coupled receptor (GPCR) that plays a central role in the renin-angiotensin-aldosterone system (RAAS), which regulates blood pressure, fluid and electrolyte balance, and systemic vascular resistance. It is the primary mediator of the physiological and pathophysiological effects of angiotensin II. Blockade of AT1 receptors using selective antagonists ("angiotensin receptor blockers," ARBs) forms a cornerstone therapy for hypertension, heart failure, diabetic nephropathy and other cardiovascular diseases.
- Other names
- AT1RAngiotensin II type-1 receptorAGTR1AG2SAGTR1A/BAt1a/b receptor
02
Mechanism of action
Selective antagonism of the AT1 receptor, blocking the effects of angiotensin II
03
Biological functions
VasoconstrictionAldosterone secretionCardiac hypertrophySodium/water retentionSignal transductionRegulation of blood pressureFluid and electrolyte balanceSystemic vascular resistanceCentral osmoregulationInflammatory response modulationExtracellular matrix formation
04
Disease associations
HypertensionHeart failureDiabetic nephropathyCardiovascular disease
05
Interacting drugs
Angiotensin receptor blockers (ARBs)
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