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Anion Transport Protein
- Molecular classification
- Transporter, SLC4 family, SLC26 family, SLC22 family
01
Overview
Anion transport proteins are integral membrane proteins responsible for the movement of inorganic and organic anions across biological membranes. They play essential roles in physiological processes such as acid-base balance, CO₂ transport, and cellular homeostasis. The most well-studied example is the Band 3 anion transport protein (also known as AE1 or SLC4A1), which mediates chloride/bicarbonate exchange in red blood cells and kidney cells. Mutations or dysfunctions in these proteins can lead to various diseases.
- Other names
- Anion exchangerBand 3AE1SLC4A1
02
Mechanism of action
Inhibition of anion exchange via binding to the protein complex.
03
Biological functions
Electroneutral Cl⁻/HCO₃⁻ exchangeCO₂ transportAcid-base balanceCellular homeostasisMembrane structure linkage
04
Disease associations
Hereditary spherocytosisSoutheast Asian ovalocytosisDistal renal tubular acidosis
05
Interacting drugs
Stilbenedisulfonates
1 more in the full profile.
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