Target intelligence / Profile preview

ANKRD40 C-terminal-like protein (ANKRD40CL)

Target
ANKRD40CL
Molecular classification
Other (Ankyrin repeat family; not classified as receptor, enzyme, etc.), Long noncoding RNA (for LINC00483)
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Overview

ANKRD40 C-terminal-like protein (ANKRD40CL) is a member of the ankyrin repeat domain protein family. The gene is located on human chromosome 17 and is sometimes referred to by its aliases C17orf73 and LINC00483, the latter denoting a long noncoding RNA. The protein is predicted to contain ankyrin repeat domains, which may serve as scaffolds for protein-protein interactions[1]. Research has linked elevated gene expression to several cancers, including pancreatic ductal adenocarcinoma, cervical and colorectal cancer, with potential biomarker relevance[4][8][2]. However, the entity is not classified as a receptor, enzyme, ion channel, or recognized drug target, and its precise biological function remains poorly characterized[4][1][8]. In summary, ANKRD40CL is best described as a gene/protein of the ankyrin repeat family with ambiguous molecular classification (sometimes annotated as noncoding RNA), but it is not a validated therapeutic target, receptor, or enzyme[1][4][8][9].

Other names
Putative ANKRD40 C-terminal-like proteinANKRD40CLC17orf73LINC00483FLJ20694long intergenic non-protein coding RNA 483GC17M050762 (Previous GeneCards ID)
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Mechanism of action

None applicable

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Biological functions

Possible involvement in RNA-mediated gene regulation (if considering LINC00483)Disease-association marker (elevated expression linked to cancer)Protein-protein interaction through ankyrin repeats (based on domain classification)
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Disease associations

Cancer (Pancreatic ductal adenocarcinoma, Cervical cancer, possibly Colorectal and Breast cancer)Other (biomarker potential for cell proliferation/disease progression)
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Biomarkers

Elevated expression of LINC00483/ANKRD40CL is studied as a prognostic marker in several cancers

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