Ankyrin repeat and SAM domain-containing protein 1A (ANKS1A)

Ankyrin repeat and SAM domain-containing protein 1A (ANKS1A, also called Odin) is a cytosolic, ubiquitously expressed adaptor/scaffolding protein encoded by the *ANKS1A* gene on chromosome 6. It contains multiple ankyrin repeats, two sterile alpha motif (SAM) domains, and a phosphotyrosine binding (PTB) domain, reflecting its modular role in protein-protein interactions. ANKS1A is a critical regulator of receptor tyrosine kinase trafficking and signaling, particularly the epidermal growth factor receptor (EGFR) and EphA2, by modulating their endoplasmic reticulum (ER) export and cell surface localization. It also regulates LDL receptor-related protein 1 (LRP1)-mediated clearance of amyloid β (Aβ) peptides across the blood-brain barrier, implicating it in Alzheimer’s disease pathophysiology. Genomic variants in *ANKS1A* are associated with increased risk for coronary artery disease. Through its scaffolding functions, ANKS1A is implicated in cancer, neurological disease, and vascular pathobiology. There are currently no known therapeutics directly targeting ANKS1A, and it is not a canonical therapeutic target such as receptor, enzyme, ion channel, or transporter.

Other names

ANKS1KIAA0229Odinankyrin repeat and sterile alpha motif domain containing 1Aankyrin repeat and SAM domain containing 1A