Ankyrin repeat and SOCS box containing 7 (ASB7)

ASB7 (Ankyrin repeat and SOCS box containing 7) is a multifunctional, ubiquitously expressed protein involved in critical cellular processes, primarily acting as a substrate recognition component within an E3 ubiquitin ligase complex (Elongin-Cullin-SOCS box, or ECS).[1][3] The protein mediates ubiquitination and subsequent proteasomal degradation of target proteins—such as DDA3/PSRC1—to control spindle dynamics, chromosome alignment, and the maintenance of genome integrity during cell division and meiosis.[1][2][3] ASB7 expression is upregulated during endoplasmic reticulum (ER) stress, modulating the unfolded protein response and pro-inflammatory cytokine levels.[1][2] ASB7 is implicated as a molecular biomarker in cardiovascular disease and with loci affecting optic nerve morphology in glaucoma.[1][3] Disruption or knockdown of ASB7 impairs spindle assembly, actin organization, and meiotic progression in oocytes, leading to increased aneuploidy and cytoskeletal defects.[2] Despite its significance in cell biology and disease, there are currently no known approved drugs or specific inhibitors that directly target ASB7 in a therapeutic context.[1][3]

Other names

Ankyrin repeat and SOCS box protein 7ASB-7ASB7_HUMAN