Ankyrin repeat and SOCS box protein 10 (ASB10)

Ankyrin repeat and SOCS box protein 10 (ASB10) is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins and functions as an E3 ubiquitin ligase, regulating protein stability and degradation through ubiquitin-mediated processes[1][2][3]. ASB10 is expressed abundantly in ocular tissues like the trabecular meshwork, where it modulates intraocular pressure and has been genetically linked to primary open-angle glaucoma[1][2]. It exerts its function by coupling ankyrin repeat-mediated substrate recognition with the SOCS box, which recruits ubiquitination machinery, targeting proteins for degradation by the proteasome or autophagy-lysosome pathway[1][2][4]. In cardiac tissues, ASB10 interacts with and stabilizes HSP70, exacerbating pathological cardiac remodeling under stress[3]. In cancer, ASB10 mediates degradation of TEM8 in response to estrogen receptor-α in triple-negative breast cancer, impacting cancer stem cell properties and neovasculogenesis[1]. Thus, ASB10 is an important regulator of protein quality control with roles in ocular physiology, cardiovascular disease, and cancer biology.

Other names

GLC1Fankyrin repeat and suppressor of cytokine signaling box containing protein 10

Drugs targeting or mimicking ASB10 activity would modulate protein ubiquitination and degradation; direct pharmacological targeting not described