Ankyrin repeat and SOCS box protein 3 (ASB3)

Ankyrin repeat and SOCS box protein 3 (ASB3) is an intracellular protein composed of an N-terminal ankyrin repeat region (typically 11–12 repeats) and a C-terminal SOCS box domain. ASB3 acts as the substrate recognition component in ECS-type cullin-RING E3 ubiquitin ligase complexes, facilitating the ubiquitination and proteasomal degradation of target proteins, most notably tumor necrosis factor receptor 2 (TNF-R2). By promoting the breakdown of TNF-R2, ASB3 negatively regulates the JNK signaling pathway and apoptosis in response to TNF-α, as well as influencing other cell signaling and immune processes. ASB3 is implicated as a negative regulator of inflammatory signaling, a modulator in cancer biology, and possibly involved in other disease processes. There are no clinically approved drugs or validated biomarkers directly targeting ASB3 currently reported.

Other names

ASB3Ankyrin repeat and SOCS box containing 3ASB-3GPR75-ASB3ankyrin repeat and SOCS box protein 3

Inhibition of TNF-R2-mediated cell signaling via substrate-targeted ubiquitination and degradation; Regulation of antiviral and inflammatory pathways by mediating degradation of MAVS and TRAF6