Ankyrin repeat and SOCS box protein 5 (ASB5)

Ankyrin repeat and SOCS box protein 5 (ASB5) is a human protein that belongs to the ankyrin repeat and SOCS box-containing (ASB) family. These proteins contain an N-terminal ankyrin repeat domain for substrate recognition and a C-terminal SOCS box for assembly with Elongin B/C, Cul5, and Rbx2, forming part of Cullin–RING E3 ubiquitin ligase complexes. ASB proteins act as substrate-adaptor components, mediating the ubiquitination and subsequent proteasomal degradation of specific targets, thereby influencing diverse cellular processes such as protein turnover, signal transduction, and possibly vascular development. The specific substrates and physiological roles of ASB5 remain under investigation, but it is categorized structurally and functionally with other ASB family proteins that regulate key pathways in cell biology and disease.

Other names

ASB5Ankyrin repeat and SOCS box-containing protein 5Ankyrin repeat and SOCS box protein 5

Inhibition or modulation of substrate recognition and ubiquitination activity (disrupts recruitment of ubiquitin E2 enzymes and substrate interaction)