Ankyrin repeat and SOCS box protein 6 (ASB6)

Ankyrin repeat and SOCS box protein 6 (ASB6) is a member of the ASB (Ankyrin repeat and SOCS box) family, proteins that contain ankyrin repeat domains for substrate recognition and a C-terminal SOCS (suppressor of cytokine signaling) box[2][3][5]. The SOCS box enables ASB6 to assemble with Elongin B/C, Cullin 5 (CUL5), and RBX2 to form ECS-type E3 ubiquitin ligase complexes responsible for ubiquitination and proteasomal degradation of specific protein substrates[1][5]. ASB6 is involved in modulating insulin signaling by targeting components of the insulin pathway for degradation in adipocytes, thus influencing glucose uptake[2][7]. In various cancers, elevated ASB6 expression is associated with increased tumor aggressiveness, maintenance of cancer stemness, and poorer prognosis[2][6]. ASB6 also regulates protein quality control via ubiquitination and degradation of autophagy-related substrate p62/SQSTM1, affecting the balance between cell proliferation, autophagy, and apoptosis[2][5]. The gene exhibits alternative splicing and may generate protein isoforms differing in SOCS box integrity, potentially influencing E3 ligase assembly and function[2]. Overall, ASB6 acts as a multifunctional adaptor regulating key metabolic and oncogenic pathways by modulating substrate degradation through the ubiquitin-proteasome system[2][5].

Other names

ASB6Ankyrin repeat and SOCS box containing 6Ankyrin and SOCS box protein 6ASB-6

Modulation of substrate protein levels by serving as a substrate-recognition component in ECS (Elongin-Cullin-SOCS box) E3 ubiquitin ligase complexes, which mediate ubiquitination and subsequent proteasomal degradation of target proteins[1][2][5].