Ankyrin repeat and ubiquitin domain-containing protein 1 (ANKUB1)

Ankyrin repeat and ubiquitin domain-containing protein 1 (ANKUB1), also known as C3orf16, is a human protein characterized by the presence of three ankyrin repeat domains, a ubiquitin domain, and a low complexity region[1][3][9][11]. Ankyrin repeats are structural motifs known to mediate protein–protein interactions, while the ubiquitin domain is associated with protein turnover and signaling, typically through interactions involved in ubiquitinylation[1][9]. ANKUB1 is not currently established as a classical therapeutic target such as a receptor, ion channel, or enzyme, and there are no known drugs or targeted therapies against it[11][13]. Frameshift mutations in ANKUB1 have been observed in rare cases of familial polysyndactyly (PSD), implicating possible functions in developmental processes, though the exact biological role remains to be validated[1]. Data suggest that ANKUB1 might act in protein regulation or cellular signaling pathways; however, its precise physiological or pathological roles remain largely uncharacterized, and it is not widely recognized as a disease gene or biomarker[1][11][13].

Other names

C3orf16protein ANKUB1ANKUB1