Ankyrin repeat and zinc finger peptidyl-tRNA hydrolase 1 (ANKZF1)

Ankyrin repeat and zinc finger peptidyl-tRNA hydrolase 1 (ANKZF1) is an endonuclease enzyme critical for protein quality control within the cell. It is responsible for cleaving polypeptidyl-tRNAs that are stalled on ribosomes during translation, a step crucial for ribosome-associated quality control (RQC)[1][2][3][4]. This cleavage event enables the release and subsequent degradation of incomplete and abnormal polypeptides, preventing the accumulation of defective proteins. ANKZF1's activity also generates tRNA fragments requiring repair before reuse in translation, and its function is linked to the cellular response to oxidative stress and maintenance of mitochondrial integrity[1][2][3][5]. ANKZF1 interacts with protein degradation networks (such as the p97/VCP ATPase system) and has been implicated in various pathological conditions, with altered expression associated with several cancers and rare mutations linked to inflammatory and immune-mediated diseases[3]. While it is emerging as a prospective therapeutic target, especially in oncology, there are currently no approved drugs or specific pharmacological modulators known for this protein[5].

Other names

tRNA endonuclease ANKZF1ZNF744FLJ10415Vms1Ankyrin repeat and zinc finger domain-containing protein 1Zinc finger protein 744ankyrin repeat and zinc finger domain containing 1