Ankyrin repeat domain-containing protein 11 (ANKRD11)

Ankyrin repeat domain-containing protein 11 (ANKRD11) is a multifunctional chromatin regulator and nuclear cofactor that modulates gene expression through interactions with nuclear receptor complexes, transcription factors (including p53), and chromatin-modifying enzymes[1][2][3]. It contains ankyrin repeats, repression domains, and an activation domain, enabling both coactivator and corepressor functions for nuclear receptors. ANKRD11 is critical in the epigenetic regulation of gene expression, especially through modification of histone acetylation, and is essential for normal neurodevelopment, bone maturation, and craniofacial formation[1][2][3][5]. Mutations in ANKRD11 cause KBG syndrome, a neurodevelopmental disorder characterized by developmental delay, intellectual disability, craniofacial and skeletal anomalies, and can also contribute to other disorders including Cornelia de Lange syndrome and some forms of cancer. ANKRD11 is not currently considered a classic druggable therapeutic target such as a receptor, enzyme, or transporter, and there are no known approved drugs that directly target or modulate the activity of this protein[1][2][3][5].

Other names

Ankyrin repeat domain-containing protein 11ANKRD11ANCO1LZ16T13ANCO-1Ankyrin repeat-containing cofactor 1ankyrin repeats containing cofactor 1nasopharyngeal carcinoma susceptibility protein