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Ankyrin repeat domain-containing protein 13B (ANKRD13B)
- Target
- ANKRD13B
- Molecular classification
- Other (Ubiquitin-binding protein; Contains ankyrin repeat domains)
01
Overview
Ankyrin repeat domain-containing protein 13B (ANKRD13B) is a cytoplasmic protein containing multiple ankyrin repeats, acting primarily as a ubiquitin-binding scaffold that recognizes 'Lys-63'-linked ubiquitin but not 'Lys-48'-linked chains. It participates in the negative regulation of receptor internalization, notably for the epidermal growth factor receptor (EGFR), by transiently promoting complex formation with molecular partners to facilitate receptor trafficking. The protein is found mainly in endosomes, the perinuclear region, and the plasma membrane, and although its involvement in receptor trafficking suggests possible relevance in disease contexts such as cancer and neuropsychiatric disorders, it is not currently classified as a therapeutic target for drug development.
- Other names
- ANKRD13BFLJ25555Ankyrin repeat domain 13Bankyrin repeat domain-containing protein 13B
02
Biological functions
Ubiquitin-modified protein reader activityNegative regulation of receptor internalizationScaffold for EGFR internalization complex
03
Disease associations
Cancer (expression noted in multiple cancers)Cataract 8, Multiple typesSchizophreniform disorder
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