Ankyrin repeat domain-containing protein 18B (ANKRD18B)

Ankyrin repeat domain-containing protein 18B (ANKRD18B) is a protein-coding gene encoding a member of the ankyrin repeat domain-containing protein family, which typically function in mediating protein–protein interactions and structural scaffolding. In particular, ANKRD18B acts as a critical scaffolding protein in retinal Mueller cells, being essential for maintaining structural integrity of the retina[3]. It is associated with diseases such as ovary serous adenocarcinoma and large intestine adenocarcinoma, although mechanistic and functional data for ANKRD18B remain limited[5]. ANKRD18B is mainly classified as an "other" protein (scaffolding protein), not a canonical drug target like a receptor, enzyme, or transporter[2][5]. No evidence currently establishes ANKRD18B as a direct therapeutic target, nor are there known drugs or mechanistic strategies specifically targeting it[2][5].

Other names

BA255A11.3BA255A11.5bA255A11.3bA255A11.5Ankyrin repeat domain 18B