Ankyrin repeat domain-containing protein 23 (ANKRD23)

Ankyrin repeat domain-containing protein 23 (ANKRD23), also called diabetes-related ankyrin repeat protein (DARP) or muscle ankyrin repeat protein 3 (MARP3), is a member of the muscle ankyrin repeat protein family. It contains four tandem ankyrin-like repeats and localizes primarily to the nucleus where it acts as a transcriptional regulator. ANKRD23 is strongly expressed in striated muscle and is upregulated during conditions of metabolic stress, such as in insulin-resistant and diabetic models. Functionally, it regulates muscle metabolism by modulating AMP-activated protein kinase (AMPK) activity and influences both fatty acid and glucose metabolism. It also acts as a negative regulator of myoblast differentiation, impacting muscle growth. In addition to its nuclear regulatory activities, ANKRD23 may contribute to mechanotransduction signaling in muscle tissue and could serve as a biomarker for muscular diseases. There is no evidence that ANKRD23 is currently a direct pharmaceutical target, but it plays important roles in muscle physiology and metabolic regulation[1][2][3][5].

Other names

Diabetes-related ankyrin repeat proteinDARPMuscle ankyrin repeat protein 3MARP3FLJ32449