Ankyrin repeat domain-containing protein 31 (ANKRD31)

Ankyrin repeat domain-containing protein 31 (ANKRD31) is a scaffold protein characterized by multiple ankyrin repeats that facilitate protein-protein interactions in meiotic cells[1][2][3][4][5]. ANKRD31 plays an essential role in initiating meiotic recombination by anchoring double-strand break-promoting factors, especially REC114, to specific locations on chromosomes, including pseudoautosomal regions of sex chromosomes[1][2][4][5]. Loss or dysfunction of ANKRD31 leads to misregulation of double-strand break formation, defective recombination, male meiotic arrest and infertility, and reduced oocyte reserve in females[1][2][4][5]. ANKRD31 is not considered a canonical therapeutic target such as a receptor, enzyme, or transporter, but instead serves as a critical scaffold for meiotic chromosomal events. There are no known drugs directly targeting ANKRD31, and no established roles in cancer, inflammation, or other complex diseases outside germ cell development.

Other names

ANKRD31FLJ40191ankyrin repeat domain 31putative ankyrin repeat domain-containing protein 31