Ankyrin repeat domain-containing protein 34B (ANKRD34B)

Ankyrin repeat domain-containing protein 34B (ANKRD34B) is a protein encoded by the human ANKRD34B gene, with the canonical UniProt ID A5PLL1. It is part of a broad family of proteins defined by the presence of ankyrin repeat motifs, which serve as common protein–protein interaction scaffolds in diverse cellular processes. The ankyrin repeat is a structural motif that mediates specific binding surfaces for molecular recognition, but ANKRD34B itself does not have a well-established, unique molecular function or enzyme activity. Bioinformatic predictions suggest its localization to the cytoplasm and nucleus, perhaps associated with structures like pi-bodies. There is a single, weak disease association (neonatal candidiasis), but the evidence is limited and does not support a therapeutic role. ANKRD34B is not currently the subject of approved or investigational drugs, nor is it used as a diagnostic or predictive biomarker. Its role, if any, in disease remains to be thoroughly characterized. - ANKRD34B is a non-enzymatic, non-receptor protein characterized by ankyrin repeat domains that likely function in general protein scaffolding and interactions, with no established direct therapeutic relevance. - There is no evidence for it being a current or emerging therapeutic target, no known small molecule modulators, and no notable safety concerns or biomarker utility.

Other names

Ankyrin repeat domain-containing protein 34BANKRD34BDendritic cell progenitor protein of 58 kDa

Not applicable; this is not presently a therapeutic target, and there are no drugs known to act via this protein