Ankyrin repeat domain-containing protein 39 (ANKRD39)

ANKRD39, or ankyrin repeat domain-containing protein 39, is a member of the ankyrin repeat domain protein family, characterized by repeating structural motifs that typically mediate protein-protein interactions[1][2]. Its gene is expressed in many tissues, but its function is largely inferred based on domain architecture and broad interaction networks rather than defined enzymatic activity or receptor function[1][5][6]. Recent transcriptomic studies in Alzheimer’s disease suggest ANKRD39 may operate as a hub gene influencing autophagy and intracellular signaling, but mechanistic details remain unclear[1]. While ankyrin repeat domains generally serve as scaffolds or adaptors in numerous cellular processes, ANKRD39 itself is not directly implicated as a receptor, enzyme, transporter, nor does it have established roles in other well-characterized molecular families[2]. Current research highlights its context-specific associations rather than direct therapeutic actions, and further experimental work is needed to define its functional role and any disease contribution[1][2][6].

Other names

Ankyrin repeat domain 39HSPC200MGC41816ANR39_HUMAN (UniProt mnemonic)Ankyrin repeat domain-containing protein 39