Ankyrin repeat domain-containing protein 7 (ANKRD7)

Ankyrin repeat domain-containing protein 7 (ANKRD7) is a protein encoded by the ANKRD7 gene in humans. The protein is 151 amino acids in length and contains multiple ankyrin repeats, structural motifs known to mediate protein–protein interactions but not associated with enzymatic activity or classical receptor/signaling functions[1][2][3]. ANKRD7 was initially cloned as a testis-specific transcript (alias TSA806), and transcriptomics analyses confirm its highly enriched expression in human testis, suggesting a role in testicular development or function, possibly related to spermatogenesis or early developmental events such as blastocyst hatching[2][5][4]. Its molecular function and physiological role remain poorly characterized, with no evidence for involvement in common disease mechanisms, no established biomarkers, and no drugs known to interact with the protein. Disease database entries mention association with Androgen Insensitivity Syndrome, but the causal or mechanistic role is unclear[4]. Summary of key points: - **ANKRD7** is **not a classical therapeutic target** (such as a receptor, enzyme, or transporter). - Functions mainly as a **putative protein–protein interaction scaffold** via ankyrin repeat domains; **biological role is not well defined** but appears testis-enriched[1][2][3][5]. - **No established disease roles or drug interactions**; thus, not currently considered for patient selection or safety monitoring in any known clinical context[4].

Other names

TSA806Testis-specific protein TSA806testicular tissue protein Li 19testis-specific ankyrin motif containing protein