Ankyrin repeat domain-containing protein pseudogene (ENSG00000255166)

The Ankyrin repeat domain-containing protein pseudogene (ENSG00000255166) is annotated as a pseudogene in the human genome, meaning it is a genetic locus that resembles a functional gene but harbors disabling mutations preventing expression of a functional protein[1][5]. Pseudogenes are often evolutionary relics and can arise by duplication (unprocessed), retrotransposition (processed), or mutation of a once-functional gene (unitary)[2][5]. Most pseudogenes are considered nonfunctional; however, a minority are transcribed and can participate in cellular regulation at the RNA level, for example by serving as microRNA decoys or generating small interfering RNAs that may modulate the expression of protein-coding genes[2][3][4]. Some pseudogenes are implicated in the dysregulation seen in cancer and other diseases, but specific roles for this locus have not been documented. The locus is not recognized as a receptor, enzyme, transporter, or other canonical therapeutic target, nor are there drugs that interact with it[1][5].

Other names

ANKRD pseudogeneAnkyrin repeat domain-containing protein (ANKRD) pseudogene