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Annexin A2 (ANXA2)
- Target
- ANXA2
- Molecular classification
- Annexin, Calcium-dependent phospholipid-binding protein
01
Overview
Annexin A2 (ANXA2) is a calcium-dependent phospholipid-binding protein involved in various cellular processes. It forms a heterotetrameric complex with S100A10 and participates in exocytosis, endocytosis, membrane organization, fibrinolysis, and cytoskeletal linkage. It is implicated in tumor progression, preeclampsia, infectious diseases, and bone resorption.
- Other names
- Annexin IICalpactin I heavy chainChromobindin-8Lipocortin IIPlacental anticoagulant protein IVProtein Ip36
02
Biological functions
ExocytosisEndocytosisMembrane organizationIon channel regulationCytoskeletal linkageFibrinolysisCell motilityCell-matrix interactionsAutocrine factor (osteoclast formation)Redox regulationEndosome sortingAnticoagulant activityModulates viral life cycles
03
Disease associations
CancerPreeclampsiaInfectious diseasesBrain tumorsBone resorption
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