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Target intelligence / Profile preview
Annexin A2 pseudogene 1 (ANXA2P1)
- Target
- ANXA2P1
- Molecular classification
- Pseudogene[5]
01
Overview
Annexin A2 pseudogene 1 (ANXA2P1) is a non-protein-coding pseudogene related to the annexin A2 gene (ANXA2). Although historically considered non-functional, emerging evidence suggests ANXA2P1 may influence cancer biology—particularly glioma—by acting as a molecular decoy that regulates the expression of its parent gene ANXA2 through a competing endogenous RNA (ceRNA) mechanism involving microRNA sequestration. Its expression level is associated with molecular subtypes of glioblastoma and may serve as a biomarker for poor prognosis, but no direct therapeutic targeting or drug interactions have been established for ANXA2P1 itself[4][5].
- Other names
- LPC2AANX2P1ANX2L1[5]
02
Biological functions
Possible regulator of parent gene expression via competitive endogenous RNA (ceRNA)/miRNA decoy roles[4]
03
Disease associations
Cancer (especially glioma and glioblastoma, where ANXA2P1 expression correlates with poor prognosis and with mesenchymal molecular subtype)[4]
04
Biomarkers
Prognosis in glioma and glioblastoma (associates with poor overall survival and mesenchymal molecular subtype)[4]
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