Annexin A2 pseudogene 3 (ANXA2P3)

Annexin A2 pseudogene 3 (ANXA2P3), also known as LIP2, is a noncoding genomic locus considered a pseudogene of the protein-coding annexin A2 (ANXA2) gene. Unlike its parental gene, ANXA2P3 does not produce a functional protein. There is little evidence of direct biological or disease-related function, though some pseudogenes related to annexin A2 have been shown to be transcribed in certain cancers, potentially serving as noncoding regulatory elements[3]. No drugs or known mechanisms of action are described for ANXA2P3, and it is not considered a therapeutic target, receptor, or biomarker[2][3]. All molecular functions, disease roles, and interaction data for annexin A2 itself (ANXA2, not ANXA2P3) should not be attributed to this pseudogene[1][2][3]. *Note: Several sources incorrectly conflate pseudogene entries with their protein-coding parental genes. All described roles in cell signaling, membrane repair, fibrinolysis, and disease (e.g., cancer progression, neurodegeneration) apply to ANXA2, not ANXA2P3[1][2].* Summary: ANXA2P3/LIP2 is a noncoding pseudogene with no established function, druggability, or major disease role. Information or targets referencing annexin A2 pseudogenes should be verified for specificity to avoid confusion with the protein-coding annexin A2 (ANXA2) molecule[2][3].

Other names

LIP2ANXA2P3

None (no protein product or targetable mechanism)