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Annexin A9 (ANXA9)
- Target
- ANXA9
- Molecular classification
- Calcium-dependent phospholipid-binding protein, Annexin family, Other
01
Overview
Annexin A9 (ANXA9) is a divergent member of the annexin family, a group of calcium-dependent phospholipid-binding proteins characterized by four internal repeat domains with type II calcium-binding sites. Unlike typical annexins, all four calcium-binding sites of ANXA9 contain substitutions that ablate their function, though its core structure retains a putative intact ion channel. ANXA9 modulates cellular adhesion, cytoskeletal organization, and membrane dynamics, and is involved in the regulation of ectodomain shedding of cell-surface ligands (notably pro-amphiregulin via the ADAM17 complex), which can impact cell signaling and migration. It is implicated as a prognostic factor in colorectal cancer and as a low affinity acetylcholine receptor in keratinocytes, where it is targeted by autoantibodies in pemphigus vulgaris[1][4][5][6].
- Other names
- Annexin A9ANXA9ANX31Annexin XXXIAnnexin-31Annexin-9Pemphaxinannexin 31annexin XXXIannexin-9pemphaxin
02
Biological functions
Modulation of cellular adhesionRegulation of membrane dynamicsCytoskeletal organizationRegulation of ectodomain shedding (pro-amphiregulin/ADAM17 complex)Paracrine signaling regulationIon channel formation (putative/structural)
03
Disease associations
Cancer (including colorectal and breast cancer)Autoimmune skin diseases (Pemphigus, a disease linked to keratinocyte targeting by pemphigus vulgaris antibodies)Other
04
Biomarkers
Prognostic biomarker for colorectal cancer (high expression correlates with worse prognosis)
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