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Anoctamine 1 (None)
- Target
- None
- Molecular classification
- Ion channel, Voltage-gated calcium-dependent anion channel
01
Overview
Anoctamine 1 (ANO1), also known as Transmembrane Member 16A (TMEM16A), is a voltage-gated, calcium-activated anion channel that functions as a chloride and bicarbonate channel. It is widely expressed in smooth muscle, epithelial cells, vomeronasal neurons, olfactory sustentacular cells, and interstitial cells of Cajal (ICC). ANO1 plays a crucial role in transepithelial anion transport, smooth muscle contraction, and gastrointestinal motility. Dysregulation of ANO1 has been linked to polycystic kidney disease and cancer, making it a potential therapeutic target.
- Other names
- TMEM16A
02
Mechanism of action
Modulation of chloride and bicarbonate transport through channel blockade or potentiation.
03
Biological functions
Chloride transportBicarbonate transportSmooth muscle contractionEpithelial secretionRegulation of transepithelial anion transportModulates intracellular Ca(^{2+}) signaling
04
Disease associations
Polycystic kidney diseaseCancerItch sensation
05
Safety considerations
Potential for off-target effects due to widespread expression.Disruption of normal smooth muscle or epithelial function.
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