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Target intelligence / Profile preview
Anthrax Protective Antigen (PA)
- Target
- PA
- Molecular classification
- Protein, Toxin component
01
Overview
Anthrax protective antigen (PA) is a protein component of the anthrax toxin produced by Bacillus anthracis. It is essential for the pathogenicity of anthrax as it mediates the entry of lethal factor (LF) and edema factor (EF) into host cells. PA binds to host cell receptors, undergoes cleavage and oligomerization, and forms a pore in endosomal membranes to translocate LF and EF into the cytosol. PA is the major immunogen in current anthrax vaccines.
02
Mechanism of action
Facilitates the entry of lethal factor (LF) and edema factor (EF) into host cells by binding to cell surface receptors, forming a pore in endosomal membranes, and translocating LF/EF into the cytosol.
03
Biological functions
Receptor bindingPore formationTranslocation of toxinsImmune response (antigen)
04
Disease associations
Infection (Bacillus anthracis)Anthrax
05
Safety considerations
Potential for off-target effects of therapeutics targeting PADevelopment of resistance by Bacillus anthracis
06
Interacting drugs
Anthrax Vaccine Adsorbed (AVA)
1 more in the full profile.
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