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Target intelligence / Profile preview
Circulating Anti-Double-Stranded DNA Antibody (Anti-dsDNA)
- Target
- Anti-dsDNA
- Molecular classification
- Autoantibody, Immunoglobulin
01
Overview
Circulating anti-double-stranded DNA (anti-dsDNA) antibodies are a subset of autoantibodies that specifically target double-stranded DNA, a key component of the cell nucleus. These antibodies are classified as anti-nuclear antibodies (ANA) and are most commonly associated with systemic lupus erythematosus (SLE), an autoimmune disease. Their presence in blood is highly specific for SLE and they play a significant role in both diagnosis and monitoring disease activity, especially lupus nephritis.
- Other names
- Anti-Double-Stranded DNA AntibodydsDNA AntibodyCirculating Anti-dsDNAAnti-dsDNA Antibodies
02
Mechanism of action
N/A - Autoantibodies are a result of disease, not a target for drugs directly.
03
Biological functions
Immune responseComplement activationImmune complex formationCellular penetration
04
Disease associations
Systemic Lupus Erythematosus (SLE)Lupus NephritisCardiovascular disease (SLE-related)Neuropsychiatric lupus
05
Safety considerations
Increased risk of infectionNephrotoxicity (related to immune complex deposition)Cardiovascular complicationsNeuropsychiatric complications
06
Interacting drugs
Belimumab
6 more in the full profile.
07
Biomarkers
Disease activity in SLELupus nephritisRisk of flaresSerum anti-dsDNA antibody titrePersistent proteinuria
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