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Target intelligence / Profile preview
Anti-inflammatory
- Molecular classification
- Enzyme, Transcription Factor, Cytokine, Receptor, Signaling Pathway
01
Overview
Anti-inflammatory is a broad pharmacological class encompassing multiple molecular targets involved in reducing or modulating inflammation. These targets include COX enzymes, LOXs, NF-kB pathway components, cytokines/receptors, and the JAK/STAT pathway. Anti-inflammatory agents work by inhibiting enzyme activity, suppressing proinflammatory signals, modulating transcription factors, interfering with cell adhesion, and enhancing endogenous anti-inflammatory pathways.
- Other names
- Modulation of InflammationInflammation Reduction
02
Mechanism of action
Inhibition/modulation of enzyme activity; suppression/blockade of proinflammatory signals; modulation of transcription factors; interference with cell adhesion; enhancement of endogenous anti-inflammatory pathways.
03
Biological functions
Immune ResponseCell SignalingRegulation of Gene ExpressionModulation of Inflammation
04
Disease associations
InflammationAutoimmune DiseasesArthritisCardiovascular DiseaseNeurodegenerative DiseasesCancer
05
Safety considerations
Side effects associated with single-target therapiesGastrointestinal issues (NSAIDs)Immunosuppression (Biologics)
06
Interacting drugs
Ibuprofen
4 more in the full profile.
07
Biomarkers
Patient-specific biomarkersDisease phenotypes
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