Target intelligence / Profile preview

Anti-inflammatory Gene Expression

Molecular classification: Gene Expression, Biological Process

Overview

Anti-inflammatory gene expression refers to the upregulation of genes that encode proteins or factors which suppress inflammation, counteract pro-inflammatory signals, and restore tissue homeostasis. Key regulators include the Glucocorticoid Receptor (GR) and the IL-10/STAT3 pathway. Mechanisms involve direct transactivation, trans-repression/tethering, chromatin remodeling, and epigenetic modifications. Examples of induced genes include Lipocortin-1, Interleukin-10, and Interleukin-1 receptor antagonist.

Mechanism of action

Not applicable

Biological functions

Immune response regulationInflammation resolutionHomeostasis maintenance

Disease associations

InflammationAutoimmune disorders

Interacting drugs

Glucocorticoids

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