Anti-inflammatory Mediators

Anti-inflammatory mediators are a diverse group of molecules that actively suppress, resolve, or limit the inflammatory response in tissues. They counteract the effects of pro-inflammatory mediators to restore tissue homeostasis after injury or infection. These include cytokines like IL-10 and specialized pro-resolving lipid mediators like lipoxins, resolvins, protectins and maresins. Their mechanisms of action include inhibition of pro-inflammatory pathways and promotion of resolution through processes such as efferocytosis. Dysregulation of these mediators contributes to chronic inflammatory diseases.

Other names

Resolution mediatorsInflammation resolving mediatorsEndogenous anti-inflammatory molecules

Varies depending on the specific mediator. Examples include inhibition of NF-kB pathway (IL-10), promotion of efferocytosis and inhibition of neutrophil infiltration (Lipoxins, Resolvins), and modulation of COX enzymes (Aspirin-triggered lipoxins).